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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323055
Species: Homo sapiens
RGD Object: Gene
Symbol: VASP
Name: vasodilator stimulated phosphoprotein
Acc ID: CHEBI:6925
Term: microcystin-LR
Definition: A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Chemical ID: MESH:C057862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VASPincreases phosphorylationEXP 6480464CTDcyanoginosin LR results in increased phosphorylation of VASP proteinPMID:24677693 PMID:27352821 PMID:27393157
VASPmultiple interactionsEXP 6480464CTD[IGBP1 protein results in increased susceptibility to cyanoginosin LR] which affects the expression of VASP protein modified form; cyanoginosin LR results in increased phosphorylation of and affects the localization of VASP protein; SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of VASP protein]; U 0126 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of VASP protein]PMID:23929704 PMID:24677693 PMID:29984889
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