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GENE - TERM ANNOTATION REPORT

RGD ID: 1322850
Species: Mus musculus
RGD Object: Gene
Symbol: Cops8
Name: COP9 signalosome subunit 8
Acc ID: GO:0008180
Term: COP9 signalosome
Definition: A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
Definition Source(s): PMID:11019806, PMID:12186635, PMID:14570571
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAFB:FBgn0261437, MGI:MGI:1915363, PANTHER:PTN000330924, UniProtKB:Q99627, dictyBase:DDB_G02754712290270GO_Central (PMID:21873635)

PMID:21873635
 IDA 2290270MGI (MGI:MGI:1298123, PMID:9707402)

MGI:MGI:1298123, PMID:9707402
 ISOUniProtKB:Q996272290270MGI GO_REF:0000096, MGI:MGI:4834177
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.