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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322513
Species: Homo sapiens
RGD Object: Gene
Symbol: SOX9
Name: SRY-box transcription factor 9
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOX9affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of SOX9 mRNAPMID:31887333
SOX9decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SOX9 mRNAPMID:20106945 PMID:29704546
SOX9increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SOX9 mRNAPMID:15056799 PMID:19619570
SOX9multiple interactionsEXP 6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SOX9 mRNA]; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SOX9 mRNAPMID:19619570 PMID:29704546
SOX9affects expressionISOSox9 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SOX9 mRNAPMID:21570461 PMID:24058054
SOX9decreases expressionISOSox9 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SOX9 mRNAPMID:15034205 PMID:19770486 PMID:37318321
SOX9multiple interactionsISOSox9 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX9 mRNA; [tributyltin co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SOX9 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SOX9 promoter]PMID:17942748 PMID:19654925 PMID:22749964
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