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GENE - TERM ANNOTATION REPORT

RGD ID: 1322461
Species: Homo sapiens
RGD Object: Gene
Symbol: IL33
Name: interleukin 33
Acc ID: DOID:2841
Term: asthma
Definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. (DO)
Definition Source(s): http://www.nhlbi.nih.gov/health/dci/Diseases/Asthma/Asthma_WhatIs.html "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK430901/ "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK7223/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL33severityIEP 39938968RGDassociated with fungal infectious disease 
IL33treatmentISOIl33 (Mus musculus)39939002RGDassociated with viral pneumonia; 
IL33 EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:19198610 PMID:21804549 PMID:24241537 PMID:27472835 PMID:29067999
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