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GENE - TERM ANNOTATION REPORT

RGD ID: 1322311
Species: Mus musculus
RGD Object: Gene
Symbol: Brms1
Name: breast cancer metastasis-suppressor 1
Acc ID: GO:0070822
Term: Sin3-type complex
Definition: Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.
Definition Source(s): PMID:15565322, PMID:18292778
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brms1part_ofIBAPANTHER:PTN001095090 or PomBase:SPBC21C3.02c or MGI:1919204 or SGD:S000000011 or SGD:S000001346 or FB:FBgn0031036 or PomBase:SPAC25B8.02 or FB:FBgn00304342290270GO_Central GO_REF:0000033
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