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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322043
Species: Homo sapiens
RGD Object: Gene
Symbol: DIABLO
Name: diablo IAP-binding mitochondrial protein
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DIABLOaffects localizationEXP 6480464CTDBortezomib affects the localization of DIABLO proteinPMID:16024631
DIABLOincreases expressionEXP 6480464CTDBortezomib results in increased expression of DIABLO mRNA; Bortezomib results in increased expression of DIABLO proteinPMID:17327374 PMID:25913414
DIABLOincreases localizationEXP 6480464CTDBortezomib results in increased localization of DIABLO proteinPMID:14555532
DIABLOmultiple interactionsEXP 6480464CTD[alvocidib co-treated with Bortezomib] results in increased secretion of DIABLO protein; [Bortezomib co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in decreased localization of DIABLO protein; [Bortezomib co-treated with Butyrates] affects the localization of DIABLO protein; [Bortezomib co-treated with TNFSF10 protein] results in increased expression of DIABLO protein; [Bortezomib co-treated with Vorinostat] affects the localization of DIABLO protein; Bortezomib inhibits the reaction [BAX mutant form inhibits the reaction [TNFSF10 protein results in increased localization of DIABLO protein]]; Bortezomib promotes the reaction [TNFSF10 protein results in increased localization of DIABLO protein]PMID:12893773 PMID:12902978 PMID:15039284 PMID:15070698
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