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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1321394
Species: Mus musculus
RGD Object: Gene
Symbol: Srf
Name: serum response factor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srfdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of SRF mRNAPMID:19770486 PMID:21715664 PMID:22228805
Srfincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of SRF mRNAPMID:22228805
Srfmultiple interactionsEXP 6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SRF mRNA]PMID:22228805
Srfaffects activityISOSRF (Homo sapiens)6480464CTDBenzo(a)pyrene affects the activity of SRF proteinPMID:20624995
Srfdecreases methylationISOSRF (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of SRF promoterPMID:27901495
Srfincreases expressionISOSrf (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of SRF proteinPMID:21467743
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