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GENE - TERM ANNOTATION REPORT

RGD ID: 1321175
Species: Homo sapiens
RGD Object: Gene
Symbol: CYFIP1
Name: cytoplasmic FMR1 interacting protein 1
Acc ID: GO:0045202
Term: synapse
Definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
Definition Source(s): GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYFIP1is_active_inIBAMGI:1338801 or MGI:1924134 or PANTHER:PTN000257567 or Cyfip1 (Rattus norvegicus) or UniProtKB:Q96F07150520179GO_Central GO_REF:0000033
CYFIP1located_inIEAPANTHER:PTHR12195:SF4150520179TreeGrafter GO_REF:0000118
CYFIP1located_inIEAUniProtKB-KW:KW-0770150520179UniProt GO_REF:0000043
CYFIP1located_inIEAUniProtKB-SubCell:SL-0258150520179UniProt GO_REF:0000044
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