Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - TERM ANNOTATION REPORT

RGD ID: 1320498
Species: Homo sapiens
RGD Object: Gene
Symbol: DIXDC1
Name: DIX domain containing 1
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): GOC:bf, GOC:dph, PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAFB:FBgn0000499, MGI:MGI:106613, MGI:MGI:108100, MGI:MGI:2679721, MGI:MGI:94941, PANTHER:PTN000093945, UniProtKB:O14640, UniProtKB:O14641, UniProtKB:Q92997, ZFIN:ZDB-GENE-030721-22290271GO_Central (PMID:21873635)

PMID:21873635
 IDA 2290271UniProtKB (PMID:21189423)

PMID:21189423
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.