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GENE - TERM ANNOTATION REPORT

RGD ID: 1320498
Species: Homo sapiens
RGD Object: Gene
Symbol: DIXDC1
Name: DIX domain containing 1
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DIXDC1involved_inIEAUniProtKB:Q80Y83 or ensembl:ENSMUSP00000034566150520179Ensembl GO_REF:0000107
DIXDC1involved_inIBAFB:FBgn0000499 or MGI:106613 or MGI:108100 or MGI:2679721 or MGI:94941 or PANTHER:PTN000093945 or UniProtKB:O14640 or UniProtKB:O14641 or UniProtKB:Q155Q3 or UniProtKB:Q92997 or ZFIN:ZDB-GENE-010319-1 or ZFIN:ZDB-GENE-030721-2150520179GO_Central GO_REF:0000033
DIXDC1involved_inIEAPANTHER:PTHR10878:SF22150520179TreeGrafter GO_REF:0000118
DIXDC1involved_inIDA 150520179UniProt PMID:21189423

PMID:21189423
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