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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320330
Species: Homo sapiens
RGD Object: Gene
Symbol: HDAC1
Name: histone deacetylase 1
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HDAC1decreases expressionEXP 6480464CTDsulforaphane results in decreased expression of HDAC1 mRNAPMID:30684530
HDAC1multiple interactionsEXP 6480464CTDsulforaphane inhibits the reaction [Estradiol promotes the reaction [HDAC1 protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Estradiol results in increased expression of HDAC1 mRNA]; sulforaphane inhibits the reaction [Genistein promotes the reaction [HDAC1 protein binds to COMT promoter]]; sulforaphane inhibits the reaction [HDAC1 protein binds to COMT promoter]PMID:30684530
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