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GENE - TERM ANNOTATION REPORT

RGD ID: 1319634
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK11
Name: mitogen-activated protein kinase 11
Acc ID: GO:0004707
Term: MAP kinase activity
Definition: Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
Definition Source(s): GOC:ma, ISBN:0198547684
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK11 ISOMapk11 (Rattus norvegicus)9068941RGD PMID:16879317 REF_RGD_ID:2298806
MAPK11enablesIEAUniProtKB:D4A3U7 or UniProtKB:Q9WUI1 or ensembl:ENSMUSP00000086204 or ensembl:ENSRNOP00000009325150520179Ensembl GO_REF:0000107
MAPK11enablesIEAInterPro:IPR003527 or InterPro:IPR008352150520179InterPro GO_REF:0000002
MAPK11enablesIDA 150520179UniProt PMID:10330143 PMID:8663524

PMID:10330143 PMID:8663524
MAPK11enablesIEAEC:2.7.11.24150520179UniProt GO_REF:0000003
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