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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319532
Species: Mus musculus
RGD Object: Gene
Symbol: Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc7a11decreases response to substanceISOSLC7A11 (Homo sapiens)6480464CTDSLC7A11 protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922
Slc7a11increases expressionISOSLC7A11 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of SLC7A11 mRNAPMID:19128835 PMID:23824090 PMID:24356939 PMID:25258189 PMID:25424538 PMID:26705709 PMID:27829220
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