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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319531
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC7A11
Name: solute carrier family 7 member 11
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC7A11affects response to substanceEXP 6480464CTDSLC7A11 gene SNP affects the susceptibility to methylmercuric chloridePMID:25622337
SLC7A11increases expressionEXP 6480464CTDmethylmercuric chloride results in increased expression of SLC7A11 mRNAPMID:23179753 PMID:26272509 PMID:27188386 PMID:28001369 PMID:32870474
SLC7A11decreases expressionISOSlc7a11 (Rattus norvegicus)6480464CTDmethylmercuric chloride results in decreased expression of SLC7A11 proteinPMID:32061141
SLC7A11increases expressionISOSlc7a11 (Rattus norvegicus)6480464CTDmethylmercuric chloride results in increased expression of SLC7A11 mRNAPMID:32061141
SLC7A11multiple interactionsISOSlc7a11 (Rattus norvegicus)6480464CTD[methylmercuric chloride affects the localization of NFE2L2 protein] which results in increased expression of SLC7A11 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA]PMID:20421342 PMID:32061141
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