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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319523
Species: Mus musculus
RGD Object: Gene
Symbol: Gli2
Name: GLI-Kruppel family member GLI2
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gli2decreases expressionISOGLI2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of GLI2 mRNAPMID:23861973 PMID:24685274 PMID:25945059
Gli2decreases response to substanceISOGLI2 (Homo sapiens)6480464CTDGLI2 protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922
Gli2increases response to substanceISOGLI2 (Homo sapiens)6480464CTDGLI2 protein results in increased susceptibility to Arsenic TrioxidePMID:21183792
Gli2multiple interactionsISOGli2 (Rattus norvegicus)6480464CTDArsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]]PMID:31612257
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