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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319353
Species: Homo sapiens
RGD Object: Gene
Symbol: CLDN14
Name: claudin 14
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CLDN14affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of CLDN14 5' UTR; Benzo(a)pyrene affects the methylation of CLDN14 promoterPMID:27901495
CLDN14decreases expressionEXP 6480464CTDBenzo(a)pyrene metabolite results in decreased expression of CLDN14 mRNA; Benzo(a)pyrene results in decreased expression of CLDN14 mRNAPMID:22316170 PMID:26238291 PMID:26314263 PMID:32234424 PMID:35690182
CLDN14increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of CLDN14 exonPMID:27901495
CLDN14decreases expressionISOCldn14 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CLDN14 mRNAPMID:19770486
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