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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319121
Species: Homo sapiens
RGD Object: Gene
Symbol: SCUBE1
Name: signal peptide, CUB domain and EGF like domain containing 1
Acc ID: CHEBI:34567
Term: benzo[e]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. It is listed as a Group 3 carcinogen by the IARC.
Chemical ID: MESH:C026487
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases methylationEXP 6480464CTDbenzo(e)pyrene results in increased methylation of SCUBE1 exon, benzo(e)pyrene results in increased methylation of SCUBE1 intron, benzo(e)pyrene results in increased methylation of SCUBE1 polyA tail

PMID:30157460
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.