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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319073
Species: Mus musculus
RGD Object: Gene
Symbol: Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkdcaffects response to substanceISOPRKDC (Homo sapiens)6480464CTDPRKDC protein affects the susceptibility to 2,2',4,4'-tetrabromodiphenyl etherPMID:22233939
Prkdcdecreases expressionISOPRKDC (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PRKDC proteinPMID:31675489
Prkdcincreases expressionISOPRKDC (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PRKDC proteinPMID:22233939
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