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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318944
Species: Mus musculus
RGD Object: Gene
Symbol: Htra2
Name: HtrA serine peptidase 2
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htra2decreases localizationISOHTRA2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased localization of HTRA2 proteinPMID:23041229
Htra2increases expressionISOHTRA2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of HTRA2 mRNAPMID:22521957
Htra2multiple interactionsISOHTRA2 (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Quercetin] affects the localization of HTRA2 protein; [Arsenic Trioxide co-treated with TNF protein] affects the localization of HTRA2 protein; [lonidamine co-treated with Arsenic Trioxide] affects the localization of HTRA2 protein; Deoxyglucose promotes the reaction [Arsenic Trioxide results in decreased localization of HTRA2 protein]PMID:17673311 PMID:18359480 PMID:21889928 PMID:23041229
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