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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318780
Species: Homo sapiens
RGD Object: Gene
Symbol: CSK
Name: C-terminal Src kinase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CSKincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CSK mRNAPMID:21802500 PMID:23152189
CSKaffects expressionISOCsk (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of CSK mRNAPMID:22298810 PMID:34747641
CSKincreases expressionISOCsk (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CSK mRNAPMID:18796159 PMID:33387578
CSKincreases response to substanceISOCsk (Mus musculus)6480464CTDCSK protein results in increased susceptibility to TetrachlorodibenzodioxinPMID:9664232
CSKmultiple interactionsISOCsk (Mus musculus)6480464CTDCSK protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]; CSK protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]]; CSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of FOS protein]; CSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CSK protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; geldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]; Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]PMID:9664232
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