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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318631
Species: Mus musculus
RGD Object: Gene
Symbol: Col6a3
Name: collagen, type VI, alpha 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col6a3affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of COL6A3 mRNAPMID:26377647
Col6a3increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of COL6A3 mRNAPMID:16922920 PMID:19933214
Col6a3multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL6A3 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of COL6A3 mRNA]PMID:15667827 PMID:16054899 PMID:17942748
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