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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318463
Species: Homo sapiens
RGD Object: Gene
Symbol: SDHB
Name: succinate dehydrogenase complex iron sulfur subunit B
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SDHBincreases expressionEXP 6480464CTDresveratrol results in increased expression of SDHB proteinPMID:24365713
SDHBincreases expressionISOSdhb (Mus musculus)6480464CTDResveratrol results in increased expression of SDHB mRNA; Resveratrol results in increased expression of SDHB proteinPMID:22610192 PMID:25394648 PMID:25505154 PMID:34216621
SDHBmultiple interactionsISOSdhb (Mus musculus)6480464CTDResveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein]; SIRT1 protein affects the reaction [Resveratrol results in increased expression of SDHB mRNA]; STK11 protein affects the reaction [Resveratrol results in increased expression of SDHB mRNA]PMID:23293585 PMID:34216621
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