GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | decreases activity | EXP | | 6480464 | CTD | Streptozocin results in decreased activity of SIRT1 protein | PMID:22058332 | Sirt1 | decreases expression | EXP | | 6480464 | CTD | Streptozocin results in decreased expression of SIRT1 protein | PMID:21778425 PMID:23859249 PMID:24889822 | Sirt1 | multiple interactions | EXP | | 6480464 | CTD | [Dietary Fats co-treated with Streptozocin] results in decreased expression of SIRT1 mRNA; [Streptozocin co-treated with Dietary Fats] results in decreased expression of SIRT1 mRNA; [Streptozocin co-treated with Dietary Fats] results in decreased expression of SIRT1 protein; AICA ribonucleotide inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SIRT1 protein]; NUS1 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SIRT1 mRNA]; Plant Extracts inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein]; SIRT1 protein inhibits the reaction [Streptozocin promotes the reaction [JUN protein binds to PARP1 protein]]; SIRT1 protein inhibits the reaction [Streptozocin promotes the reaction [PARP1 protein binds to MMP9 promoter]]; SIRT1 protein inhibits the reaction [Streptozocin promotes the reaction [RELA protein binds to PARP1 protein]]; SIRT1 protein inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; SIRT1 protein inhibits the reaction [Streptozocin results in decreased expression of SOD2]; SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN1A]; SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]; SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SERPINE1]; SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SHC1 mRNA]; SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SHC1 protein]; SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of TRP53]; tianhuang inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SIRT1 mRNA]; tianhuang inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SIRT1 protein] | PMID:21778425 PMID:22058332 PMID:22744176 PMID:23859249 PMID:24889822 PMID:28478229 PMID:33812996 PMID:37337224 | Sirt1 | decreases expression | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | Streptozocin results in decreased expression of SIRT1 mRNA; Streptozocin results in decreased expression of SIRT1 protein | PMID:22733486 PMID:23792339 PMID:24740756 PMID:25301743 PMID:35442559 | Sirt1 | multiple interactions | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | [Streptozocin co-treated with bisphenol A] results in decreased expression of SIRT1 protein; [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of SIRT1 protein; [Streptozocin co-treated with Resveratrol] results in increased expression of SIRT1 protein; Organoselenium Compounds inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein]; STUB1 inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] | PMID:22733486 PMID:23792339 PMID:24740756 PMID:25301743 PMID:31062909 PMID:35187753 PMID:35442559 | | ||||||||||||||||||||||
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