GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | multiple interactions | EXP | | 6480464 | CTD | [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein; [Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA; [Rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein; [sodium arsenite co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA; Palmitic Acid promotes the reaction [[sodium arsenite co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA]; sodium arsenite promotes the reaction [[Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA] | PMID:29288687 PMID:34968464 | Sirt1 | decreases expression | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | Dexamethasone results in decreased expression of SIRT1 mRNA; Dexamethasone results in decreased expression of SIRT1 protein | PMID:33619658 | Sirt1 | increases expression | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | Dexamethasone results in increased expression of SIRT1 mRNA | PMID:19853017 | Sirt1 | multiple interactions | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | [Dexamethasone promotes the reaction [FOXO1 protein binds to SIRT1 protein]] which results in decreased acetylation of FOXO1 protein; Dexamethasone promotes the reaction [FOXO1 protein binds to SIRT1 protein]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of SIRT1 mRNA]; SIRT1 protein inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA]; SIRT1 protein inhibits the reaction [EP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]] | PMID:17884810 PMID:20181797 PMID:33619658 | Sirt1 | multiple interactions | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]; SIRT1 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SIRT1 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]]; SIRT1 protein results in increased susceptibility to [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] | PMID:26435214 | | ||||||||||||||||||||||
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