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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318375
Species: Mus musculus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:34674
Term: dextran sulfate
Definition: A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.
Chemical ID: MESH:D016264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1decreases expressionEXP 6480464CTDDextran Sulfate results in decreased expression of SIRT1 mRNA; Dextran Sulfate results in decreased expression of SIRT1 proteinPMID:19940103 PMID:24548422
Sirt1multiple interactionsEXP 6480464CTDADAM17 protein affects the reaction [Dextran Sulfate results in decreased expression of SIRT1 mRNA]; resveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of SIRT1 mRNA]; resveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of SIRT1 protein]PMID:19940103 PMID:24548422
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