GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | decreases expression | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | chromium hexavalent ion results in decreased expression of SIRT1 mRNA; chromium hexavalent ion results in decreased expression of SIRT1 protein | PMID:35024197 | Sirt1 | multiple interactions | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | [Potassium Dichromate results in increased abundance of chromium hexavalent ion] inhibits the reaction [TP53 protein modified form binds to SIRT1 protein]; [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of SIRT1 mRNA; [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of SIRT1 protein; Resveratrol inhibits the reaction [chromium hexavalent ion results in decreased expression of SIRT1 mRNA] | PMID:30974164 PMID:35024197 PMID:35307491 PMID:36849043 | | ||||||||||||||||||||||
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