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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318375
Species: Mus musculus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1decreases expressionISOSIRT1 (Homo sapiens)6480464CTDlead acetate results in decreased expression of SIRT1 proteinPMID:34842334
Sirt1multiple interactionsISOSirt1 (Rattus norvegicus)6480464CTD[lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 protein; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 protein]PMID:33978298
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTDSRT1720 inhibits the reaction [lead acetate results in decreased expression of SIRT1 protein]PMID:34842334
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