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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318375
Species: Mus musculus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:28741
Term: sodium fluoride
Definition: A metal fluoride salt with a Na(+) counterion.
Chemical ID: MESH:D012969
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1decreases expressionEXP 6480464CTDSodium Fluoride results in decreased expression of SIRT1 mRNAPMID:37739047
Sirt1increases expressionEXP 6480464CTDSodium Fluoride results in increased expression of SIRT1 mRNAPMID:24296261
Sirt1multiple interactionsEXP 6480464CTDSodium Fluoride results in increased phosphorylation of and results in increased activity of SIRT1 protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA]PMID:24296261 PMID:37739047
Sirt1multiple interactionsISOSirt1 (Rattus norvegicus)6480464CTDSodium Fluoride results in increased phosphorylation of and results in increased expression of SIRT1 proteinPMID:24296261
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