Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1318375
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Sirt1
Name:	sirtuin 1

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Sirt1	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of SIRT1 protein	PMID:26723870
Sirt1	multiple interactions	EXP		6480464	CTD	Cisplatin results in decreased expression of and results in decreased activity of SIRT1 protein; NQO1 gene mutant form inhibits the reaction [Cisplatin results in increased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]	PMID:21593185 PMID:26723870
Sirt1	decreases activity	ISO	Sirt1 (Rattus norvegicus)	6480464	CTD	Cisplatin results in decreased activity of SIRT1 protein	PMID:33661552
Sirt1	decreases expression	ISO	Sirt1 (Rattus norvegicus)	6480464	CTD	Cisplatin results in decreased expression of SIRT1 mRNA	PMID:33522649 PMID:33661552
Sirt1	decreases expression	ISO	SIRT1 (Homo sapiens)	6480464	CTD	Cisplatin results in decreased expression of SIRT1 protein	PMID:37497868
Sirt1	decreases response to substance	ISO	SIRT1 (Homo sapiens)	6480464	CTD	SIRT1 protein results in decreased susceptibility to Cisplatin	PMID:21416250
Sirt1	increases expression	ISO	Sirt1 (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of SIRT1 protein	PMID:21416250
Sirt1	multiple interactions	ISO	Sirt1 (Rattus norvegicus)	6480464	CTD	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [betanin inhibits the reaction [Cisplatin results in decreased activity of SIRT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [betanin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA]]; 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA]; betanin inhibits the reaction [Cisplatin results in decreased activity of SIRT1 protein]; betanin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA]	PMID:33522649 PMID:33661552
Sirt1	multiple interactions	ISO	SIRT1 (Homo sapiens)	6480464	CTD	[Cisplatin co-treated with jinfukang] results in decreased expression of SIRT1 mRNA; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of SIRT1 mRNA	PMID:27392435 PMID:30871063

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