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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318375
Species: Mus musculus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1increases chemical synthesisEXP 6480464CTDSIRT1 protein results in increased chemical synthesis of Reactive Oxygen SpeciesPMID:29134718
Sirt1multiple interactionsISOSirt1 (Rattus norvegicus)6480464CTDSIRT1 protein affects the reaction [[Hydrogen Peroxide results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of NDUFA13 protein]PMID:23891692
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