GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | SIRT1 | decreases activity | EXP | | 6480464 | CTD | Palmitic Acid results in decreased activity of SIRT1 protein | PMID:25943029 | SIRT1 | multiple interactions | EXP | | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]; [Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein; [Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]; [Palmitic Acid co-treated with Glucose] results in increased oxidation of and results in decreased activity of SIRT1 protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein]; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]]; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased oxidation of and results in decreased activity of SIRT1 protein]; Resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]; SIRT1 protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased acetylation of TP53 protein]; SIRT1 protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased cleavage of CASP3 protein]; SIRT1 protein inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]; SIRT1 protein mutant form inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased expression of BBC3 mRNA]; SIRT1 protein mutant form inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased expression of CDKN1A mRNA]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]] | PMID:24451382 PMID:25943029 PMID:32730863 | SIRT1 | decreases expression | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | Palmitic Acid results in decreased expression of SIRT1 mRNA; Palmitic Acid results in decreased expression of SIRT1 protein | PMID:22968147 PMID:25108154 PMID:37244597 | SIRT1 | increases expression | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | Palmitic Acid results in increased expression of SIRT1 mRNA | PMID:34968464 | SIRT1 | multiple interactions | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | [Ethanol co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein; Lead promotes the reaction [Palmitic Acid results in decreased expression of SIRT1 protein]; Palmitic Acid promotes the reaction [Lead results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Palmitic Acid results in decreased expression of SIRT1 mRNA]; SRT1720 inhibits the reaction [Lead promotes the reaction [Palmitic Acid results in decreased expression of SIRT1 protein]]; SRT1720 inhibits the reaction [Palmitic Acid promotes the reaction [Lead results in decreased expression of SIRT1 protein]] | PMID:22968147 PMID:26854922 PMID:37244597 | SIRT1 | multiple interactions | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | [Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA; Palmitic Acid inhibits the reaction [sodium arsenite results in increased expression of SIRT1 mRNA]; Palmitic Acid promotes the reaction [[sodium arsenite co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA]; sodium arsenite inhibits the reaction [Palmitic Acid results in increased expression of SIRT1 mRNA]; sodium arsenite promotes the reaction [[Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA] | PMID:34968464 | | ||||||||||||||||||||||
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