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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318201
Species: Homo sapiens
RGD Object: Gene
Symbol: LOXL2
Name: lysyl oxidase like 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LOXL2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of LOXL2 mRNAPMID:20106945 PMID:21632981 PMID:21998131
LOXL2affects expressionISOLoxl2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of LOXL2 mRNAPMID:34747641
LOXL2decreases expressionISOLoxl2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of LOXL2 mRNAPMID:19770486 PMID:33956508
LOXL2increases expressionISOLoxl2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of LOXL2 mRNAPMID:27562557
LOXL2multiple interactionsISOLoxl2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LOXL2 promoter]PMID:19654925
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