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GENE - TERM ANNOTATION REPORT

RGD ID: 1318182
Species: Mus musculus
RGD Object: Gene
Symbol: Taf8
Name: TATA-box binding protein associated factor 8
Acc ID: GO:0005669
Term: transcription factor TFIID complex
Definition: A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
Definition Source(s): GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISOUniProtKB:Q7Z7C82290270MGI (MGI:MGI:2679136, PMID:14580349)

GO_REF:0000096, MGI:MGI:2679136, MGI:MGI:4834177, PMID:14580349
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.