GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NLRP3 | increases expression | ISO | Nlrp3 (Rattus norvegicus) | 6480464 | CTD | Palmitic Acid results in increased expression of NLRP3 mRNA; Palmitic Acid results in increased expression of NLRP3 protein | PMID:30259999 PMID:37244597 | NLRP3 | increases expression | ISO | Nlrp3 (Mus musculus) | 6480464 | CTD | Palmitic Acid results in increased expression of NLRP3 protein | PMID:29031535 | NLRP3 | multiple interactions | ISO | Nlrp3 (Rattus norvegicus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA]; imoxin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA]; Lead promotes the reaction [Palmitic Acid results in increased expression of NLRP3 protein]; Palmitic Acid promotes the reaction [Lead results in increased expression of NLRP3 protein]; parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA]; SRT1720 inhibits the reaction [Lead promotes the reaction [Palmitic Acid results in increased expression of NLRP3 protein]]; SRT1720 inhibits the reaction [Palmitic Acid promotes the reaction [Lead results in increased expression of NLRP3 protein]]; SRT1720 inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein] | PMID:30259999 PMID:37244597 | NLRP3 | multiple interactions | ISO | Nlrp3 (Mus musculus) | 6480464 | CTD | baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein]; NLRP3 inhibits the reaction [Palmitic Acid results in increased cleavage of CASP1 protein]; NLRP3 inhibits the reaction [Palmitic Acid results in increased expression of IL1B protein]; ursodoxicoltaurine inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein] | PMID:27689324 PMID:29031535 | | ||||||||||||||||||||||
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