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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317785
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Acc ID: CHEBI:46081
Term: fluconazole
Definition: A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
Chemical ID: MESH:D015725
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c65decreases activityISOCYP2C9 (Homo sapiens)6480464CTDFluconazole results in decreased activity of CYP2C9 proteinPMID:15328084 PMID:15843491 PMID:26599973
Cyp2c65multiple interactionsISOCYP2C9 (Homo sapiens)6480464CTD[Fluconazole results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; Fluconazole affects the reaction [CYP2C9 gene polymorphism affects the metabolism of Flurbiprofen]; Fluconazole binds to and results in decreased activity of CYP2C9 protein; Fluconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]PMID:16081671 PMID:18378563 PMID:26599973 PMID:28887089
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