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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317784
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2C9
Name: cytochrome P450 family 2 subfamily C member 9
Acc ID: CHEBI:27999
Term: tolbutamide
Definition: An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Chemical ID: MESH:D014044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2C9affects hydroxylationEXP 6480464CTDCYP2C9 protein affects the hydroxylation of TolbutamidePMID:9170147
CYP2C9affects metabolic processingEXP 6480464CTDCYP2C9 gene polymorphism affects the metabolism of Tolbutamide; CYP2C9 gene SNP affects the metabolism of Tolbutamide; CYP2C9 protein affects the metabolism of TolbutamidePMID:11875364 PMID:12426520 PMID:15045499 PMID:15327588 PMID:15626586
CYP2C9decreases hydroxylationEXP 6480464CTDCYP2C9 gene SNP results in decreased hydroxylation of TolbutamidePMID:9170147
CYP2C9decreases metabolic processingEXP 6480464CTDCYP2C9 gene polymorphism results in decreased metabolism of TolbutamidePMID:10208645 PMID:9110362
CYP2C9increases chemical synthesisEXP 6480464CTDCYP2C9 protein results in increased chemical synthesis of Tolbutamide metabolitePMID:23850985
CYP2C9increases hydrolysisEXP 6480464CTDCYP2C9 protein results in increased hydrolysis of TolbutamidePMID:11377097
CYP2C9increases hydroxylationEXP 6480464CTDCYP2C9 protein results in increased hydroxylation of TolbutamidePMID:10611138 PMID:12433797 PMID:15843491 PMID:2025243 PMID:22634058 PMID:25994031 PMID:26255664 PMID:26763401 PMID:9110362 PMID:9522436
CYP2C9increases metabolic processingEXP 6480464CTDCYP2C9 protein results in increased metabolism of TolbutamidePMID:10208645 PMID:12464242 PMID:12467917 PMID:15155557 PMID:15370959 PMID:16124035 PMID:17267297 PMID:17565714 PMID:17702393 PMID:19082874 PMID:19715737 PMID:21915887 PMID:23850985 PMID:32198085
CYP2C9multiple interactionsEXP 6480464CTD[CYP2C9 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide; Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; acetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 protein binds to and affects the metabolism of Tolbutamide; Fenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; phenthoate inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; pranlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; profenofos inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased hydrolysis of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Ticlopidine inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Tolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; zafirlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]PMID:10611138 PMID:11377097 PMID:15370959 PMID:15856409 PMID:16081671 PMID:21915887 PMID:22634058 PMID:23850985 PMID:25994031 PMID:32198085
CYP2C9increases metabolic processingISOCyp2c65 (Mus musculus)6480464CTDCYP2C65 protein results in increased metabolism of TolbutamidePMID:30503582
CYP2C9multiple interactionsISOCyp2c65 (Mus musculus)6480464CTD[CYP2C65 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamidePMID:30503582
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