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GENE - TERM ANNOTATION REPORT

RGD ID: 1317606
Species: Homo sapiens
RGD Object: Gene
Symbol: WNT3A
Name: Wnt family member 3A
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
WNT3Ainvolved_inIDA 150520179BHF-UCL PMID:16890161 PMID:18941195 PMID:19101069 PMID:19736317 PMID:20137080 PMID:20559569 PMID:20723538 PMID:23797875 PMID:28733458

PMID:16890161 PMID:18941195 PMID:19101069 PMID:19736317 PMID:20137080 PMID:20559569 PMID:20723538 PMID:23797875 PMID:28733458
WNT3Ainvolved_inIEAUniProtKB:P27467 or ensembl:ENSMUSP00000010044150520179Ensembl GO_REF:0000107
WNT3Ainvolved_inIBAFB:FBgn0004360 or FB:FBgn0031902 or FB:FBgn0284084 or MGI:101948 or MGI:108061 or MGI:1197020 or MGI:1261834 or MGI:2446084 or MGI:98953 or MGI:98954 or MGI:98955 or MGI:98956 or MGI:98957 or MGI:98958 or MGI:98961 or MGI:98962 or PANTHER:PTN000246517 or Wnt7a (Rattus norvegicus) or UniProtKB:O00744 or UniProtKB:O00755 or UniProtKB:O14904 or UniProtKB:O14905 or UniProtKB:P04628 or UniProtKB:P09544 or UniProtKB:P56703 or UniProtKB:P56704 or UniProtKB:P56705 or UniProtKB:P56706 or UniProtKB:Q2LMP1 or UniProtKB:Q93097 or UniProtKB:Q93098 or UniProtKB:Q98SN7 or UniProtKB:Q9GZT5 or UniProtKB:Q9H1J5 or WB:WBGene00001188 or WB:WBGene00003395 or ZFIN:ZDB-GENE-980526-332 or ZFIN:ZDB-GENE-990415-279150520179GO_Central GO_REF:0000033
WNT3Aacts_upstream_of_or_withinISOWnt3a (Mus musculus)9068941MGI PMID:31222549

PMID:31222549
WNT3Ainvolved_inTAS 150520179ParkinsonsUK-UCL PMID:22988876

PMID:22988876
WNT3Ainvolved_inIEAARBA:ARBA00026624150520179UniProt GO_REF:0000117
WNT3Ainvolved_inIMP 150520179UniProt PMID:26902720

PMID:26902720
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