Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316919
Species: Homo sapiens
RGD Object: Gene
Symbol: SP8
Name: Sp8 transcription factor
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDValproic Acid affects the expression of SP8 mRNA

PMID:25979313
decreases expressionEXP 6480464CTDValproic Acid results in decreased expression of SP8 mRNA

PMID:23179753, PMID:24383497, PMID:26272509, PMID:28001369
decreases methylationEXP 6480464CTDValproic Acid results in decreased methylation of SP8 gene

PMID:29154799
multiple interactionsEXP 6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SP8 mRNA

PMID:27188386
affects expressionISORGD:13169206480464CTDValproic Acid affects the expression of SP8 mRNA

PMID:17292431
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.