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GENE - TERM ANNOTATION REPORT

RGD ID: 1316669
Species: Homo sapiens
RGD Object: Gene
Symbol: CLDN17
Name: claudin 17
Acc ID: GO:0005923
Term: bicellular tight junction
Definition: An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
Definition Source(s): GOC:mah, ISBN:0815332181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CLDN17is_active_inIBAMGI:106925 or MGI:1276109 or MGI:1276110 or MGI:1276112 or MGI:1313314 or MGI:1329044 or MGI:1859284 or MGI:1859285 or MGI:1859286 or MGI:1860425 or MGI:1913100 or MGI:1913101 or MGI:2148742 or MGI:3033992 or PANTHER:PTN000243505 or Cldn16 (Rattus norvegicus) or Cldn1 (Rattus norvegicus) or Cldn3 (Rattus norvegicus) or UniProtKB:O00501 or UniProtKB:O14493 or UniProtKB:O15551 or UniProtKB:O95832 or UniProtKB:Q2HJ22 or UniProtKB:Q8N6F1 or UniProtKB:Q98SR2 or ZFIN:ZDB-GENE-040426-1305 or ZFIN:ZDB-GENE-040718-145150520179GO_Central GO_REF:0000033
CLDN17located_inIEAInterPro:IPR006187150520179InterPro GO_REF:0000002
CLDN17located_inIEAPANTHER:PTHR12002:SF75150520179TreeGrafter GO_REF:0000118
CLDN17located_inIEAUniProtKB-KW:KW-0796150520179UniProt GO_REF:0000043
CLDN17located_inIEAUniProtKB-SubCell:SL-0265150520179UniProt GO_REF:0000044
CLDN17located_inISSUniProtKB:Q9Z0G9150520179UniProt GO_REF:0000024
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