GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ryr1 | affects abundance | ISO | RYR1 (Homo sapiens) | 6480464 | CTD | RYR1 protein polymorphism affects the abundance of Calcium | PMID:16372898 | Ryr1 | increases abundance | ISO | RYR1 (Homo sapiens) | 6480464 | CTD | RYR1 gene mutant form results in increased abundance of Calcium | PMID:19191329 | Ryr1 | increases secretion | ISO | RYR1 (Homo sapiens) | 6480464 | CTD | RYR1 protein mutant form results in increased secretion of Calcium | PMID:18719443 | Ryr1 | multiple interactions | ISO | RYR1 (Homo sapiens) | 6480464 | CTD | [Caffeine results in increased activity of RYR1 protein] which affects the localization of Calcium; [chlorocresol results in increased activity of RYR1 protein] which affects the localization of Calcium; [chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium; [Halothane results in increased activity of RYR1 protein] which affects the localization of Calcium; [RYR1 protein co-treated with 2,3,6,2',3',6'-hexachlorobiphenyl] affects the susceptibility to Calcium; Calcium affects the folding of [CALM1 protein binds to RYR1 protein modified form]; Calcium affects the reaction [CALM1 protein binds to and affects the activity of RYR1 protein]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]; RYR1 protein polymorphism affects the reaction [Caffeine results in increased secretion of Calcium]; RYR1 protein polymorphism affects the reaction [chlorocresol results in increased secretion of Calcium] | PMID:15381065 PMID:16372898 PMID:17707769 PMID:18954145 PMID:21485675 | Ryr1 | multiple interactions | ISO | Ryr1 (Rattus norvegicus) | 6480464 | CTD | Calcium affects the reaction [CALM1 protein binds to and affects the activity of RYR1 protein]; Calcium affects the reaction [CALM1 protein modified form binds to and affects the activity of RYR1 protein] | PMID:15628869 | | ||||||||||||||||||||||
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