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GENE - TERM ANNOTATION REPORT

RGD ID: 1316339
Species: Mus musculus
RGD Object: Gene
Symbol: Sav1
Name: salvador family WW domain containing 1
Acc ID: GO:0035329
Term: hippo signaling
Definition: An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.
Definition Source(s): PMID:17318211, PMID:18328423, PMID:36347846
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sav1involved_inIBAPANTHER:PTN0087177412290270GO_Central MGI:6201960 PMID:21873635

MGI:6201960 PMID:21873635
Sav1acts_upstream_of_or_withinIGIMGI:103262 or MGI:1333883 or MGI:1354386 or MGI:19290042290270MGI MGI:3785211 PMID:18369314

MGI:3785211 PMID:18369314
Sav1acts_upstream_of_or_withinIMPMGI:2654594 or MGI:44305382290270MGI MGI:4948149 PMID:21512031

MGI:4948149 PMID:21512031
Sav1involved_inIMP 2290270UniProt MGI:4420842 PMID:20080689

MGI:4420842 PMID:20080689
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