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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316171
Species: Mus musculus
RGD Object: Gene
Symbol: Col4a1
Name: collagen, type IV, alpha 1
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col4a1increases expressionEXP 6480464CTDFolic Acid results in increased expression of COL4A1 mRNAPMID:29380373
Col4a1multiple interactionsEXP 6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL4A1 mRNA; Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of COL4A1 mRNA]; Metformin inhibits the reaction [Folic Acid results in increased expression of COL4A1 mRNA]PMID:20938992 PMID:22206623 PMID:29380373
Col4a1multiple interactionsISOCOL4A1 (Homo sapiens)6480464CTDFolic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL4A1 mRNA]PMID:29380373
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