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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316170
Species: Homo sapiens
RGD Object: Gene
Symbol: COL4A1
Name: collagen type IV alpha 1 chain
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COL4A1decreases expressionISOCol4a1 (Mus musculus)6480464CTDStreptozocin results in decreased expression of COL4A1 mRNAPMID:15496156
COL4A1increases expressionISOCol4a1 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of COL4A1 mRNAPMID:11798618 PMID:27997345
COL4A1increases expressionISOCol4a1 (Mus musculus)6480464CTDStreptozocin results in increased expression of COL4A1 mRNAPMID:17582205
COL4A1multiple interactionsISOCol4a1 (Rattus norvegicus)6480464CTDbenazepril inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]; MFN2 protein mutant form inhibits the reaction [Streptozocin promotes the reaction [TFAP2A protein binds to COL4A1 promoter]]; MFN2 protein mutant form inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]; Streptozocin promotes the reaction [TFAP2A protein binds to COL4A1 promoter]PMID:11798618 PMID:27997345
COL4A1multiple interactionsISOCol4a1 (Mus musculus)6480464CTD[fatostatin co-treated with Streptozocin] results in increased expression of COL4A1 mRNAPMID:29420703
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