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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315922
Species: Mus musculus
RGD Object: Gene
Symbol: Ercc1
Name: excision repair cross-complementing rodent repair deficiency, complementation group 1
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ercc1affects response to substanceISOERCC1 (Homo sapiens)6480464CTDERCC1 gene polymorphism affects the susceptibility to oxaliplatin; ERCC1 protein affects the susceptibility to oxaliplatinPMID:15041737 PMID:15655543 PMID:16773204 PMID:20979931
Ercc1increases expressionISOERCC1 (Homo sapiens)6480464CTDoxaliplatin results in increased expression of ERCC1 mRNAPMID:16773204
Ercc1multiple interactionsISOERCC1 (Homo sapiens)6480464CTDERCC1 gene polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin]; ERCC1 gene SNP affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin]PMID:15213713 PMID:17401013 PMID:18448328
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