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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315695
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1C1
Name: aldo-keto reductase family 1 member C1
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1C1increases expressionEXP 6480464CTDReactive Oxygen Species results in increased expression of AKR1C1 mRNAPMID:9973208
AKR1C1multiple interactionsEXP 6480464CTD[Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 mRNA; [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 proteinPMID:19320734
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