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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315603
Species: Mus musculus
RGD Object: Gene
Symbol: Lrig1
Name: leucine-rich repeats and immunoglobulin-like domains 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrig1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of LRIG1 mRNAPMID:21570461
Lrig1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of LRIG1 mRNAPMID:26290441
Lrig1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of LRIG1 mRNAPMID:18691609
Lrig1increases response to substanceEXP 6480464CTDLRIG1 results in increased susceptibility to TetrachlorodibenzodioxinPMID:28973660
Lrig1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRIG1 mRNA; LRIG1 affects the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; LRIG1 affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:17942748 PMID:28973660
Lrig1decreases expressionISOLRIG1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of LRIG1 mRNAPMID:20106945 PMID:21632981 PMID:26238291
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