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GENE - TERM ANNOTATION REPORT

RGD ID: 1315492
Species: Mus musculus
RGD Object: Gene
Symbol: Rev1
Name: REV1, DNA directed polymerase
Acc ID: GO:0070987
Term: error-free translesion synthesis
Definition: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
Definition Source(s): GOC:elh
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rev1involved_inIBAPANTHER:PTN000117973 or PomBase:SPBC1347.01c or SGD:S0000058732290270GO_Central GO_REF:0000033
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