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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315470
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC39A4
Name: solute carrier family 39 member 4
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC39A4affects expressionEXP 6480464CTDZinc affects the expression of SLC39A4 proteinPMID:20479680
SLC39A4decreases expressionEXP 6480464CTDZinc results in decreased expression of SLC39A4 mRNA; Zinc results in decreased expression of SLC39A4 proteinPMID:15753530 PMID:17202136
SLC39A4increases transportEXP 6480464CTDSLC39A4 protein results in increased transport of ZincPMID:18326752
SLC39A4increases uptakeEXP 6480464CTDSLC39A4 protein results in increased uptake of ZincPMID:17202136
SLC39A4multiple interactionsEXP 6480464CTDAmmonium Chloride inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; methyl-beta-cyclodextrin inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; Sucrose inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein]; Zinc results in increased ubiquitination of and results in increased degradation of SLC39A4 proteinPMID:17202136
SLC39A4affects expressionISOSlc39a4 (Mus musculus)6480464CTDZinc affects the expression of SLC39A4 mRNAPMID:16682017
SLC39A4affects localizationISOSlc39a4 (Mus musculus)6480464CTDZinc affects the localization of SLC39A4 protein; Zinc deficiency affects the localization of SLC39A4 proteinPMID:12801924 PMID:14709598 PMID:15358787
SLC39A4decreases expressionISOSlc39a4 (Mus musculus)6480464CTDZinc deficiency results in decreased expression of SLC39A4 mRNA; Zinc results in decreased expression of SLC39A4 mRNA; Zinc results in decreased expression of SLC39A4 proteinPMID:12514265 PMID:12801924 PMID:17202136 PMID:18020946
SLC39A4increases expressionISOSlc39a4 (Mus musculus)6480464CTDZinc deficiency results in increased expression of SLC39A4 mRNA; Zinc deficiency results in increased expression of SLC39A4 proteinPMID:12801924 PMID:15358787 PMID:18020946
SLC39A4increases response to substanceISOSlc39a4 (Mus musculus)6480464CTDSLC39A4 gene mutant form results in increased susceptibility to Zinc deficiencyPMID:17483098
SLC39A4increases uptakeISOSlc39a4 (Mus musculus)6480464CTDSLC39A4 protein results in increased uptake of ZincPMID:12801924 PMID:14709598 PMID:15322118
SLC39A4multiple interactionsISOSlc39a4 (Mus musculus)6480464CTDCycloheximide inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Cycloheximide inhibits the reaction [Zinc results in decreased expression of SLC39A4 mRNA]; Dactinomycin inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Dactinomycin inhibits the reaction [Zinc results in decreased expression of SLC39A4 mRNA]; Zinc affects the localization of and results in increased degradation of SLC39A4 protein; Zinc deficiency results in increased expression of and results in increased stability of SLC39A4 mRNA; Zinc inhibits the reaction [Zinc deficiency results in increased expression of and results in increased stability of SLC39A4 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Zinc inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 protein]PMID:12801924 PMID:18020946
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