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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315457
Species: Homo sapiens
RGD Object: Gene
Symbol: BACH1
Name: BTB domain and CNC homolog 1
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BACH1increases expressionEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BACH1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BACH1 proteinPMID:33434570
BACH1increases ubiquitinationEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 proteinPMID:28645578
BACH1multiple interactionsEXP 6480464CTD2-tert-butylhydroquinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] affects the localization of BACH1 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of BACH1 protein; [Hemin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of BACH1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tetrachlorobenzoquinone results in increased degradation of BACH1 protein]; hydroquinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]; quinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]PMID:27393035 PMID:28645578 PMID:33434570
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