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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315043
Species: Homo sapiens
RGD Object: Gene
Symbol: MAP3K5
Name: mitogen-activated protein kinase kinase kinase 5
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAP3K5increases expressionEXP 6480464CTDGlucose results in increased expression of MAP3K5 proteinPMID:16731828
MAP3K5multiple interactionsEXP 6480464CTDGlucose deficiency promotes the reaction [DAXX protein binds to MAP3K5 protein]; Glucose results in increased phosphorylation of and results in increased activity of MAP3K5 proteinPMID:14505347 PMID:16731828
MAP3K5multiple interactionsISOMap3k5 (Mus musculus)6480464CTD[[[[Glucose results in decreased expression of MIR17 mRNA] which results in increased expression of TXNIP mRNA] which results in increased expression of TXNIP protein] promotes the reaction [TXNIP protein binds to TXN1 protein]] which results in increased activity of MAP3K5 protein; [Glucose promotes the reaction [TXNIP protein binds to TXN1 protein]] which results in increased activity of MAP3K5 protein; Glucose results in increased phosphorylation of and results in increased activity of MAP3K5 proteinPMID:26660634
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