GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CA9 | increases expression | EXP | | 6480464 | CTD | [Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of ABCC2 mRNA; [Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of ALDH1A1 mRNA; [Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of ALDH1A1 protein; [Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of IGF1 mRNA; [Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of LIN28A mRNA; [Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of SOX2 mRNA; [Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of TWIST1 mRNA; [Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of WNT2 mRNA; Oxygen deficiency results in increased expression of CA9; Oxygen deficiency results in increased expression of CA9 mRNA; Oxygen deficiency results in increased expression of CA9 protein | PMID:18924134 PMID:19154183 PMID:19502547 PMID:19695866 PMID:19808899 PMID:20042640 PMID:20526721 PMID:21361354 PMID:21851094 PMID:22745725 PMID:23424623 PMID:24403227 PMID:25030372 PMID:25043185 PMID:25351418 PMID:26305601 PMID:26540049 PMID:27292261 PMID:29630948 PMID:29690507 PMID:33245928 PMID:34520103 | CA9 | multiple interactions | EXP | | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [Oxygen deficiency promotes the reaction [ARNT protein binds to CA9 promoter]]; (+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; (+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; 4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; 4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; [4-(4-((2',3',4',6'-tetra-O-acetylglucopyranosyl)thiomethyl)-5-iodo-1-H-1,2,3-triazol-1-yl)benzenesulfonamide inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]] which results in increased expression of CA12 protein; betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; Betulinic Acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; Bezafibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; Butyric Acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; CA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of ABCC2 mRNA]; CA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of ALDH1A1 mRNA]; CA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of LIN28A mRNA]; CA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of TWIST1 mRNA]; CA9 mutant form inhibits the reaction [[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of WNT2 mRNA]; CAY10591 inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; Clofibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; cobaltiprotoporphyrin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; cobaltiprotoporphyrin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; Fenofibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; Fenofibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; Gemfibrozil inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; genipin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; GSK1210151A inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; HIF1A mRNA promotes the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; molibresib inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; Oxygen deficiency promotes the reaction [ARNT protein binds to CA9 promoter]; Oxygen deficiency promotes the reaction [BRD4 protein binds to CA9 promoter]; PTEN protein promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; Vorinostat inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein] | PMID:19154183 PMID:19808899 PMID:20042640 PMID:21851094 PMID:22745725 PMID:24403227 PMID:25351418 PMID:26305601 PMID:26540049 PMID:27292261 PMID:29630948 PMID:34520103 | CA9 | increases expression | ISO | Car9 (Rattus norvegicus) | 6480464 | CTD | Oxygen deficiency results in increased expression of CAR9 protein | PMID:36527649 | CA9 | increases expression | ISO | Car9 (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased expression of CA9; Oxygen deficiency results in increased expression of CA9 mRNA | PMID:19154183 PMID:21361354 | CA9 | multiple interactions | ISO | Car9 (Mus musculus) | 6480464 | CTD | ARNT protein affects the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA] | PMID:19154183 | | ||||||||||||||||||||||
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